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Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development

29 Dec 2011

Abstract excerpt

Runx2 is a known master transcription factor for osteoblast differentiation, as well as an essential regulator for chondrocyte maturation. Recently, more and more data has shown that Runx2 regulates hypertrophic chondrocyte-specific type X collagen gene (Col10a1) expression in different species. However, how Runx2 regulation of Col10a1 expression impacts chondrocyte maturation, an essential step of endochondral...

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PMID: 22223437
DOI: 10.1002/jcp.24045

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