Article
Variable mutations of the RB gene in small-cell lung carcinoma.
Oncogene - 1 Nov 1990
Mori N, Yokota J, Akiyama T, Sameshima Y, Okamoto A, Mizoguchi H, Toyoshima K, Sugimura T, Terada M
Abstract excerpt
Loss of heterozygosity for chromosome 13q including the RB locus is a common genetic alteration in small-cell lung carcinoma (SCLC) as well as in retinoblastoma. We examined the RB cDNA sequences of exon 13 to 18 and exon 19 to 23 in 9 SCLC cell lines to detect mutations which cause inactivation of the remaining allele of the RB gene. Internal deletions of RB cDNA were observed in 3 of the 9 SCLC cell lines. In...
Topics
- Alleles
- Base Sequence
- Carcinoma, Small Cell
- Chromosome Deletion
- Chromosomes, Human, Pair 13
- Codon
- DNA
- Exons
- Genes, Retinoblastoma
- Humans
- Immunosorbent Techniques