Article
Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer.
Cancer research - 15 May 1990
Hensel C H, Hsieh C L, Gazdar A F, Johnson B E, Sakaguchi A Y, Naylor S L, Lee W H, Lee E Y
Abstract excerpt
Karyotypic and molecular genetic evidence has indicated that deletion or rearrangement of both chromosomes 3 and 13 may be important in the pathology of human small cell lung cancer (SCLC). The retinoblastoma susceptibility gene, RB, on chromosome 13 band q14, has previously been shown to be alte...
Topics
- Alleles
- Blotting, Western
- Carcinoma, Small Cell
- Chromosome Deletion
- Chromosomes, Human, Pair 13
- Gene Expression
- Gene Rearrangement
- Genes, Neoplasm
- Humans
- Lung Neoplasms
- Phosphoproteins
- Phosphorylation
- RNA, Messenger
- RNA, Neoplasm
- Retinoblastoma Protein
- Tumor Cells, Cultured