Article
Allelotype and replication error phenotype of small cell lung carcinoma.
Carcinogenesis - 1 Nov 1997
Kawanishi M, Kohno T, Otsuka T, Adachi J, Sone S, Noguchi M, Hirohashi S, Yokota J
Abstract excerpt
Allelotype and replication error (RER) phenotype analyses were performed to clarify the pathogenetic significance of inactivation of tumor suppressor genes and genomic instability in the genesis and progression of small cell lung carcinoma (SCLC). We examined 37 cases of SCLC for loss of heterozygosity (LOH) and microsatellite instability at 49 loci on all 39 nonacrocentric chromosomal arms. LOH was frequently...
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