Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of Retinoblastoma Gene Inactivation in the Spectrum of Neuroendocrine Lung Tumors

1 Feb 1998

Abstract excerpt

The retinoblastoma (RB) gene plays a key role in cell cycle control by regulation of G1 growth arrest. This gene is inactivated in some human cancers and in most small-cell lung carcinoma (SCLC) cell lines. The aim of this study was to analyze the mechanisms of RB silencing in freshly excised neuroendocrine (NE) tumors embracing the entire spectrum of NE lung neoplasms (typical and atypical carcinoids, large-cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lung Cancer Research Studies
Share to Neuroendocrine Tumor Research Advances
Share to Ocular Oncology and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9476905
DOI: 10.1165/ajrcmb.18.2.3008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of Retinoblastoma Gene Inactivation in the Spectrum of Neuroendocrine Lung TumorsPMID 9476905Read ↗

Genetic alterations in early‐stage pulmonary large cell neuroendocrine carcinomaSemantic proximity Read ↗

Quantitative expansion of structural genomic alterations in the spectrum of neuroendocrine lung carcinomas.Semantic proximity Read ↗

Rb Tumor Suppressor in Small Cell Lung Cancer: Combined Genomic and IHC Analysis with a Description of a Distinct Rb-Proficient SubsetSemantic proximity Read ↗

P53 and Rb Aberrations in Small Cell Lung Cancer (SCLC): From Molecular Mechanisms to Therapeutic ModulationSemantic proximity Read ↗

Expression of Retinoid Receptor Genes and Proteins in Non-Small-Cell Lung CancerSemantic proximity Read ↗

Retinoblastoma Regulatory Pathway in Lung CancerSemantic proximity Read ↗

Histopathologic and genetic alterations as predictors of response to treatment and survival in lung cancer: a review of published data.Semantic proximity Read ↗

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.Semantic proximity Read ↗

Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cellsSemantic proximity Read ↗

Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancerSemantic proximity Read ↗

RB1 Genetic Alterations in Estrogen Receptor-Positive Breast Carcinomas: Correlation With Neuroendocrine Differentiation.Semantic proximity Read ↗

Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.