Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor suppressor genes involved in metastasis of lung and colorectal carcinomas.

Princess Takamatsu symposia - 1 Jan 1991

Yokota J, Ookawa K, Nishikawa R, Sameshima Y

Abstract excerpt

Inactivation of tumor suppressor genes is now believed to play an important role in various progression stages of human cancers. To clarify the possible involvement of tumor suppressor gene inactivation in the acquisition of metastatic potential in lung and colorectal carcinoma cells, we examined various genetic alterations in both primary tumors and metastases obtained from patients with lung and colorectal...

Topics

Colorectal Neoplasms
Gene Deletion
Genes, Tumor Suppressor
Humans
Lung Neoplasms
Mutation
Neoplasm Metastasis

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1844253

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1844253-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor suppressor genes involved in metastasis of lung and colorectal carcinomas.PMID 1844253Read ↗

Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma.Semantic proximity Read ↗

Detailed deletion mapping suggests the involvement of a tumor suppressor gene at 17p13.3, distal to p53, in the pathogenesis of lung cancers.Semantic proximity Read ↗

p53 alterations in non-small cell lung cancers correlate with metastatic involvement of hilar and mediastinal lymph nodes.Semantic proximity Read ↗

Oncogenes and tumor-suppressor genes.Semantic proximity Read ↗

Three new regions on chromosome 17p13.3 distal to p53 with possible tumor suppressor gene involvement in lung cancer.Semantic proximity Read ↗

Variable mutations of the RB gene in small-cell lung carcinoma.Semantic proximity Read ↗

Genetic alterations responsible for metastatic phenotypes of lung cancer cells.Semantic proximity Read ↗

Deletion of three distinct regions on chromosome 13q in human non-small-cell lung cancerSemantic proximity Read ↗

[Loss of heterozygosity involving DCC gene in human colorectal cancers is correlated with the metastatic potential].Semantic proximity Read ↗

Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.Semantic proximity Read ↗

Detection of DCC and Ki-ras gene alterations in colorectal carcinoma tissue as prognostic markers for liver metastatic recurrence.Semantic proximity Read ↗

Mutation and expression of the DCC gene in human lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.