Transformation by simian virus 40 does not involve the mutational activation of p53 to an oncogenic form.

doi:10.1016/0042-6822(90)90258-s

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Article

Transformation by simian virus 40 does not involve the mutational activation of p53 to an oncogenic form.

Virology - 1 May 1990

Lin J Y, Simmons D T

Abstract excerpt

We investigated whether the p53 protein of SV40-transformed mouse cells reacted with the conformation-dependent monoclonal antibody pAb246. This antibody can usually distinguish between a p53 with anti-proliferative activity like the wild-type protein (pAb246+) and a mutated form of p53 with onco...

Topics

Animals
Antibodies, Monoclonal
Cell Line, Transformed
Cell Transformation, Viral
Glycoproteins
Mice
Mice, Inbred BALB C
Mutation
Simian virus 40
Virus Activation

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