p53 undergoes epitopic changes in vitro by sodium-vanadate.

Article

p53 undergoes epitopic changes in vitro by sodium-vanadate.

Oncogene - 1 Apr 1994

Landesman Y, Bringold F, Kimchi A

Abstract excerpt

p53 has at least two conformations that differ in their immunoreactivity. They consist of the functional tumor suppressor form, characteristic of the wild type p53 and the mutant form, generated by changes in the primary amino acid sequence of the protein. It has been previously shown that the wi...

Topics

Antibodies, Monoclonal
Cell Line, Transformed
Epitopes
Genes, p53
Humans
Mutation
Nucleic Acid Conformation
Vanadates

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