Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer.

doi:10.1172/JCI114710

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Article

Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer.

The Journal of clinical investigation - 1 Jul 1990

Takahashi T, D'Amico D, Chiba I, Buchhagen D L, Minna J D

Abstract excerpt

The p53 gene initially was thought to be an oncogene, but recent evidence suggests that wild-type p53 can function as a tumor suppressor gene in lung, colon, and breast cancer as well as less common malignancies. This study reports the first identification of intronic point mutations as a mechanism for inactivation of the p53 tumor suppressor gene. Abnormally sized p53 mRNAs found in a small cell and a non-small...

Topics

Amino Acid Sequence
Base Sequence
Carcinoma, Small Cell
DNA
DNA, Neoplasm
Genes
Humans
Lung Neoplasms
Molecular Sequence Data
Mutation
Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphoproteins

Polymerase Chain Reaction

Precipitin Tests

RNA, Messenger

Tumor Cells, Cultured

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 2164047
DOI: 10.1172/JCI114710
PMCID: PMC296731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2164047-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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