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Article

Splicing mutations in TP53 in human squamous cell carcinoma lines influence immunohistochemical detection.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Feb 2002

Eicheler Wolfgang, Zips Daniel, Dörfler Annegret, Grénman Reidar, Baumann Michael

Abstract excerpt

The mutational status of the tumor suppressor gene TP53 is often examined by immunohistochemistry. We compared the incidence of TP53 mutations in 12 permanent squamous cell carcinoma lines of the head and neck with the immunohistochemical staining obtained with two different antibodies. The mutational status of the TP53 gene was assessed by sequencing the complete coding frame of the TP53 mRNA. All 12 tumor cell...

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PMID: 11799138
DOI: 10.1177/002215540205000207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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