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Article

Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations.

The pharmacogenomics journal - 1 Feb 2013

Wheeler H E, Gamazon E R, Stark A L, O'Donnell P H, Gorsic L K, Huang R S, Cox N J, Dolan M E

Abstract excerpt

Platinating agents are used in the treatment of many cancers, yet they can induce toxicities and resistance that limit their utility. Using previously published and additional world population panels of diverse ancestry totaling 608 lymphoblastoid cell lines (LCLs), we performed meta-analyses of over 3 million single-nucleotide polymorphisms (SNPs) for both carboplatin- and cisplatin-induced cytotoxicity. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21844884
DOI: 10.1038/tpj.2011.38
PMCID: PMC3370147

Genes

BCL2
ERCC2
ERCC6
GSTM1
GSTT1
NBAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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