Article
Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.
Cancer cell - 11 May 2020
Carrot-Zhang Jian, Chambwe Nyasha, Damrauer Jeffrey S, Knijnenburg Theo A, Robertson A Gordon, Yau Christina, Zhou Wanding, Berger Ashton C, Huang Kuan-Lin, Newberg Justin Y, Mashl R Jay, Romanel Alessandro, Sayaman Rosalyn W, Demichelis Francesca, Felau Ina, Frampton Garrett M, Han Seunghun, Hoadley Katherine A, Kemal Anab, Laird Peter W, Lazar Alexander J, Le Xiuning, Oak Ninad, Shen Hui, Wong Christopher K, Zenklusen Jean C, Ziv Elad, Cherniack Andrew D, Beroukhim Rameen
Abstract excerpt
We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas. We demonstrated that cancer subtypes and ancestry-related technical artifacts are important confounders that have been insufficiently accounted for. Once accounted for, ancestry-associated differences spanned all molecular features and hundreds...
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