Article
Genetic variants associated with carboplatin-induced cytotoxicity in cell lines derived from Africans.
Molecular cancer therapeutics - 1 Sept 2008
Huang R Stephanie, Duan Shiwei, Kistner Emily O, Hartford Christine M, Dolan M Eileen
Abstract excerpt
To gain a better understanding of the genetic variants associated with carboplatin-induced cytotoxicity in individuals of African descent, we present a step-wise approach integrating genotypes, gene expression, and sensitivity of HapMap cell lines to carboplatin. Cell lines derived from 30 trios of African descent (YRI) were used to develop a preclinical model to identify genetic variants and gene expression that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.