Article
Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2011
Huang R Stephanie, Johnatty Sharon E, Gamazon Eric R, Im Hae Kyung, Ziliak Dana, Duan Shiwei, Zhang Wei, Kistner Emily O, Chen Peixian, Beesley Jonathan, Mi Shuangli, O'Donnell Peter H, Fraiman Yarden S, Das Soma, Cox Nancy J, Lu Yi, Macgregor Stuart, Goode Ellen L, Vierkant Robert A, Fridley Brooke L, Hogdall Estrid, Kjaer Susanne K, Jensen Allan, Moysich Kirsten B, Grasela Matthew, Odunsi Kunle, Brown Robert, Paul Jim, Lambrechts Diether, Despierre Evelyn, Vergote Ignace, Gross Jenny, Karlan Beth Y, Defazio Anna, Chenevix-Trench Georgia, Dolan M Eileen
Abstract excerpt
PURPOSE: Cell-based approaches were used to identify genetic markers predictive of patients' risk for poor response prior to chemotherapy. EXPERIMENTAL DESIGN: We conducted genome-wide association studies (GWAS) to identify single-nucleotide polymorphisms (SNP) associated with cellular sensitivity to carboplatin through their effects on mRNA expression using International HapMap lymphoblastoid cell lines (LCL)...
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