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Article

CaMK-II is a PKD2 target that promotes pronephric kidney development and stabilizes cilia

14 Jul 2011

Abstract excerpt

Intracellular Ca²⁺ signals influence gastrulation, neurogenesis and organogenesis through pathways that are still being defined. One potential Ca²⁺ mediator of many of these morphogenic processes is CaMK-II, a conserved calmodulin-dependent protein kinase. Prolonged Ca²⁺ stimulation converts CaMK-II into an activated state that, in the zebrafish, is detected in the forebrain, ear and kidney. Autosomal dominant...

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PMID: 21752935
DOI: 10.1242/dev.066340

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