Article
The regulatory 1α subunit of protein kinase A modulates renal cystogenesis.
American journal of physiology. Renal physiology - 1 Sept 2017
Ye Hong, Wang Xiaofang, Constans Megan M, Sussman Caroline R, Chebib Fouad T, Irazabal María V, Young William F, Harris Peter C, Kirschner Lawrence S, Torres Vicente E
Abstract excerpt
The failure of the polycystins (PCs) to function in primary cilia is thought to be responsible for autosomal dominant polycystic kidney disease (ADPKD). Primary cilia integrate multiple cellular signaling pathways, including calcium, cAMP, Wnt, and Hedgehog, which control cell proliferation and differentiation. It has been proposed that mutated PCs result in reduced intracellular calcium, which in turn...
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