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Article

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2011

Choi Yun-Hee, Suzuki Akira, Hajarnis Sachin, Ma Zhendong, Chapin Hannah C, Caplan Michael J, Pontoglio Marco, Somlo Stefan, Igarashi Peter

Abstract excerpt

Polycystic kidney disease (PKD) is a genetic disorder that is characterized by cyst formation in kidney tubules. PKD arises from abnormalities of the primary cilium, a sensory organelle located on the cell surface. Here, we show that the primary cilium of renal epithelial cells contains a protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclic Nucleotide Phosphodiesterases, Type 4

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Source

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Identifiers

PMID: 21670265
DOI: 10.1073/pnas.1016214108
PMCID: PMC3127890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21670265-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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