Article

Kidney cystogenesis in embryonic- and adult-onset ADPKD is suppressed from lack of adenylyl cyclase targeting to cilia

2025-05-29

Abstract excerpt

Multiple cellular pathways are dysregulated in autosomal dominant polycystic kidney disease (ADPKD), but mechanisms initiating cyst formation are unknown. ADPKD is caused by mutations in Pkd1/Pkd2 genes that encode for polycystins that localize to primary cilia. The primary cilium is a miniscule subcellular compartment for generating signaling outputs that profoundly affect cellular function. Severe cystogenesis...

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Literature Corpus work: 6cfab059-5361-590f-bea8-95a4598233ed
DOI: 10.1101/2025.05.27.656198

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