Article
A zebrafish forward genetic screen identifies an indispensable threonine residue in the kinase domain of PRKD2.
Biology open - 9 Mar 2021
Giardoglou Panagiota, Bournele Despina, Park Misun, Kanoni Stavroula, Dedoussis George V, Steinberg Susan F, Deloukas Panos, Beis Dimitris
Abstract excerpt
Protein kinase D2 belongs to a family of evolutionarily conserved enzymes regulating several biological processes. In a forward genetic screen for zebrafish cardiovascular mutants, we identified a mutation in the prkd2 gene. Homozygous mutant embryos develop as wild type up to 36 h post-fertilization and initiate blood flow, but fail to maintain it, resulting in a complete outflow tract stenosis. We identified a...
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