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Article

Phosphodiesterase 1A modulates cystogenesis in zebrafish.

Journal of the American Society of Nephrology : JASN - 1 Oct 2014

Sussman Caroline R, Ward Christopher J, Leightner Amanda C, Smith Jordan L, Agarwal Reema, Harris Peter C, Torres Vicente E

Abstract excerpt

Substantial evidence indicates the importance of elevated cAMP in polycystic kidney disease (PKD). Accumulation of cAMP in cystic tissues may be, in part, caused by enhanced adenylyl cyclase activity, but inhibition of cAMP degradation by phosphodiesterases (PDE) likely has an important role, because cAMP is inactivated much faster than it is synthesized. PDE1 is the only PDE family activated by Ca(2+), which is...

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Identifiers

PMID: 24700876
DOI: 10.1681/ASN.2013040421
PMCID: PMC4178429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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