Article

Phosphoproteomic profiling highlights CDC42 and CDK2 as key players in the regulation of the TGF-β pathway in <i>ALMS1</i> and <i>BBS1</i> knockout models

2022-11-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> The primary cilium is a sensory organelle that extends from the plasma membrane. It plays a vital role in physiological and developmental processes by controlling different signalling pathways such as WNT, Sonic hedgehog (SHh), and transforming growth factor β (TGF-β). Ciliary dysfunction has been related to different pathologies such as Alström (ALMS) or Bardet-Biedl (BBS)...

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Literature Corpus work: f86cbc71-6598-5d6c-bd71-931462205199
DOI: 10.1101/2022.11.04.514246

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