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Article

Towards an understanding of the role of NOD2/CARD15 in the pathogenesis of Crohn's disease.

Best practice & research. Clinical gastroenterology - 1 Jun 2004

Philpott Dana J, Viala Jérôme

Abstract excerpt

With the recent discovery of NOD2 as the first susceptibility gene linked with Crohn's disease, research is now focused on attempting to explain the biological role of NOD2 and how mutations can contribute to the development of this inflammatory disease. Biochemical studies have revealed that NOD2 is in fact a protein involved in the innate immune detection of bacterial products. More specifically, NOD2...

Read the complete abstract on PubMed

Topics

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Share to Carrier Proteins
Share to Crohn Disease
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Intracellular Signaling Peptides and Proteins

Share to Nod2 Signaling Adaptor Protein

Share to Receptors, Cell Surface

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Source

Identifiers

PMID: 15157827
DOI: 10.1016/j.bpg.2003.12.004

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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