Article
The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders.
Journal of dermatological science - 1 Aug 2005
Kambe Naotomo, Nishikomori Ryuta, Kanazawa Nobuo
Abstract excerpt
Pattern-recognition receptors are a first line of defense against invading pathogens. Recent advances in the understanding of innate immunity have revealed a novel family of cytosolic pattern-recognition receptors called Nods, which contain an amino-terminal effector-binding domain, a centrally located nucleotide-binding oligomerization domain (NOD) and a carboxy-terminal ligand recognition domain. Hereditary...
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