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Article

Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival.

Oncogene - 11 Sept 2003

Muratovska Aleksandra, Zhou Chaoming, He Shuji, Goodyer Paul, Eccles Michael R

Abstract excerpt

The paired-box (PAX) genes encode a family of nine well-characterized paired-box transcription factors, with important roles in development and disease. Although PAX genes are primarily expressed in the embryo, constitutive expression promotes tissue hyperplasia. Rare tumor-specific mutations of PAX genes implicate an oncogenic role, and persistent PAX expression characterizes several tumors. Yet, a cancer-wide...

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Source

Identifiers

PMID: 12970747
DOI: 10.1038/sj.onc.1206766

Genes

PAX2
HRAS
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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