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Article

NOD2/CARD15 mutations and presence of granulomas in pediatric and adult Crohn's disease.

Inflammatory bowel diseases - 1 Nov 2004

Shaoul Ron, Karban Amir, Weiss Batia, Reif Shimon, Wasserman Dror, Pacht Avi, Eliakim Rami, Wardi Joram, Shirin Haim, Wine Eitan, Leshinsky-Silver Esther, Levine Arie

Abstract excerpt

OBJECTIVES: The etiology and mechanism leading to granuloma formation in patients with Crohn's disease (CD) are presently unknown. The first susceptibility gene to be identified as a risk factor for CD is the NOD2/CARD15 gene on Chromosome 16. Mutations in NOD2 could affect the intracellular response to bacterial products and may eventually lead to granuloma formation. The association between NOD2 and granulomas...

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Source

Identifiers

PMID: 15626887
DOI: 10.1097/00054725-200411000-00003

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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