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Article

NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease.

The American journal of gastroenterology - 1 May 2008

Angelberger Sieglinde, Reinisch Walter, Dejaco Clemens, Miehsler Wolfgang, Waldhoer Thomas, Wehkamp Jan, Lichtenberger Cornelia, Schaeffeler Elke, Vogelsang Harald, Schwab Matthias, Teml Alexander

Abstract excerpt

OBJECTIVES: The Crohn's disease (CD) susceptibility gene, nucleotide-binding oligomerizetion domain 2 (NOD2)/caspase recruitment domain 15 (CARD15), is linked to the innate immune response associated with altered epithelial bacterial defense. Its relevance in antibiotic therapy of perianal fistulating CD remains elusive. The aim of the study was to explore systematically the association between NOD2/CARD15...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18371140
DOI: 10.1111/j.1572-0241.2007.01741.x

Genes

NOD2
HBD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease.PMID 18371140Read ↗

CARD15 mutations and perianal fistulating Crohn's disease: correlation and predictive value of antibiotic response.Semantic proximity Read ↗

Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients.Semantic proximity Read ↗

Antimicrobial peptide response to blood translocation of bacterial DNA in Crohn's disease is affected by NOD2/CARD15 genotype.Semantic proximity Read ↗

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NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis.Semantic proximity Read ↗

NOD2/CARD15 does not influence response to infliximab in Crohn's disease.Semantic proximity Read ↗

Mutations in the NOD2/CARD15 gene in Crohn's disease are associated with ileocecal resection and are a risk factor for reoperation.Semantic proximity Read ↗

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