Article
Ki-ras and p53 mutations in pancreatic ductal adenocarcinoma.
Pancreas - 1 Jan 1996
Rall C J, Yan Y X, Graeme-Cook F, Beauchamp R, Yandell D W, Povoski S P, Rustgi A K
Abstract excerpt
Pancreatic adenocarcinoma involves activation of the Ki-ras oncogene, inactivation of the p53 tumor suppressor gene, and dysregulation of growth factors and perhaps metastasis genes. Ki-ras oncogene point mutations are known to be involved in pancreatic oncogenesis. The p53 tumor suppressor gene product plays a critical role in cell cycle regulation and also functions as a nuclear transcription factor. Point...
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