Isolation of compensatory inhibitor domain mutants to novel activation domain variants using the split-ubiquitin screen.

Abstract excerpt

The control of transcription factor function plays an important role in the development of many processes in eukaryotes, such as drug resistance in fungi and human tumours undergoing chemotherapy. Detailed molecular mapping of the interactions between transcription factors and their protein partners can give important information about their mechanisms of action and reveal potential therapeutic targets. We...

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