Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Purification and characterization of the yeast negative regulatory protein GAL80.

The Journal of biological chemistry - 15 Jan 1991

Yun S J, Hiraoka Y, Nishizawa M, Takio K, Titani K, Nogi Y, Fukasawa T

Abstract excerpt

Transcription of the GAL genes encoding the enzymes responsible for galactose metabolism in the yeast Saccharomyces cerevisiae is regulated through an interplay of two regulatory proteins, GAL4 and GAL80. GAL4 binds to upstream activating sequences of GAL (UASG) and activates their transcription in yeast growing in the presence of galactose. GAL80 binds to GAL4 and inhibits the activation function of GAL4 in...

Topics

Chromatography, Gel
Electrophoresis, Polyacrylamide Gel
Fungal Proteins
Molecular Weight
Mutation
Peptides
Repressor Proteins
Saccharomyces cerevisiae Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1985957

Genes

GAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1985957-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Purification and characterization of the yeast negative regulatory protein GAL80.PMID 1985957Read ↗

Nondissociation of GAL4 and GAL80 in vivo after galactose induction.Semantic proximity Read ↗

Gal80 proteins of Kluyveromyces lactis and Saccharomyces cerevisiae are highly conserved but contribute differently to glucose repression of the galactose regulon.Semantic proximity Read ↗

Gal80 dimerization and the yeast GAL gene switch.Semantic proximity Read ↗

GAL4 mutations that separate the transcriptional activation and GAL80-interactive functions of the yeast GAL4 protein.Semantic proximity Read ↗

Self-association of the Gal4 inhibitor protein Gal80 is impaired by Gal3: evidence for a new mechanism in the GAL gene switch.Semantic proximity Read ↗

Replacement of a conserved tyrosine by tryptophan in Gal3p of Saccharomyces cerevisiae reduces constitutive activity: implications for signal transduction in the GAL regulon.Semantic proximity Read ↗

Genetic evidence for similar negative regulatory domains in the yeast transcription activators GAL4 and LAC9.Semantic proximity Read ↗

Isolation and characterization of xylitol-assimilating mutants of recombinant Saccharomyces cerevisiae.Semantic proximity Read ↗

Galactose induction in yeast involves association of Gal80p with Gal1p or Gal3p.Semantic proximity Read ↗

Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p-activated genes of Saccharomyces cerevisiae.Semantic proximity Read ↗

Novel Gal3 proteins showing altered Gal80p binding cause constitutive transcription of Gal4p-activated genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Two alternative pathways of transcription initiation in the yeast negative regulatory gene GAL80.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.