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Article

Sites for interaction between Gal80p and Gal1p in Kluyveromyces lactis: structural model of galactokinase based on homology to the GHMP protein family.

Journal of molecular biology - 24 Oct 2003

Menezes R A, Amuel C, Engels R, Gengenbacher U, Labahn J, Hollenberg C P

Abstract excerpt

The induction of transcription of the galactose genes in yeast involves the galactose-dependent binding of ScGal3p (in Saccharomyces cerevisiae) or KlGal1p (in Kluyveromyces lactis) to Gal80p. This binding abrogates Gal80's inhibitory effect on the activation domain of Gal4p, which can then activate transcription. Here, we describe the isolation and characterization of new interaction mutants of K.lactis GAL1 and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14556739
DOI: 10.1016/j.jmb.2003.08.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sites for interaction between Gal80p and Gal1p in Kluyveromyces lactis: structural model of galactokinase based on homology to the GHMP protein family.PMID 14556739Read ↗

Galactose induction in yeast involves association of Gal80p with Gal1p or Gal3p.Semantic proximity Read ↗

Gal80 proteins of Kluyveromyces lactis and Saccharomyces cerevisiae are highly conserved but contribute differently to glucose repression of the galactose regulon.Semantic proximity Read ↗

Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p.Semantic proximity Read ↗

Contribution of amino acid side chains to sugar binding specificity in a galactokinase, Gal1p, and a transcriptional inducer, Gal3p.Semantic proximity Read ↗

The effect of ligand binding on the galactokinase activity of yeast Gal1p and its ability to activate transcription.Semantic proximity Read ↗

Comparative genetic and physiological studies of the MAP kinase Mpk1p from Kluyveromyces lactis and Saccharomyces cerevisiae.Semantic proximity Read ↗

Sequence conservation in the Saccharomyces and Kluveromyces GAL11 transcription activators suggests functional domains.Semantic proximity Read ↗

GAL4 mutations that separate the transcriptional activation and GAL80-interactive functions of the yeast GAL4 protein.Semantic proximity Read ↗

Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase.Semantic proximity Read ↗

Novel Gal3 proteins showing altered Gal80p binding cause constitutive transcription of Gal4p-activated genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Regulation of glycolysis by casein kinase I (Rag8p) in Kluyveromyces lactis involves a DNA-binding protein, Sck1p, a homologue of Sgc1p of Saccharomyces cerevisiae.Semantic proximity Read ↗

Characterization of KLBCK1, encoding a MAP kinase kinase kinase of Kluyveromyces lactis.Semantic proximity Read ↗

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