Article
Activation domain-dependent monoubiquitylation of Gal4 protein is essential for promoter binding in vivo.
The Journal of biological chemistry - 2 May 2008
Archer Chase T, Delahodde Agnes, Gonzalez Fernando, Johnston Stephen Albert, Kodadek Thomas
Abstract excerpt
The Saccharomyces cerevisiae Gal4 protein is a paradigmatic transcriptional activator containing a C-terminal acidic activation domain (AD) of 34 amino acids. A mutation that results in the truncation of about two-thirds of the Gal4AD (gal4D) results in a crippled protein with only 3% the activity of the wild-type activator. We show here that although the Gal4D protein is not intrinsically deficient in DNA...
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