Article
A chemical switch for inhibitor-sensitive alleles of any protein kinase.
Nature - 21 Sept 2000
Bishop A C, Ubersax J A, Petsch D T, Matheos D P, Gray N S, Blethrow J, Shimizu E, Tsien J Z, Schultz P G, Rose M D, Wood J L, Morgan D O, Shokat K M
Abstract excerpt
Protein kinases have proved to be largely resistant to the design of highly specific inhibitors, even with the aid of combinatorial chemistry. The lack of these reagents has complicated efforts to assign specific signalling roles to individual kinases. Here we describe a chemical genetic strategy...
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