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Article

Gal80 dimerization and the yeast GAL gene switch.

Genetics - 1 Apr 2005

Pilauri Vepkhia, Bewley Maria, Diep Cuong, Hopper James

Abstract excerpt

The Saccharomyces cerevisiae Gal80 protein has two binding partners: Gal4 and Gal3. In the absence of galactose, Gal80 binds to and inhibits the transcriptional activation domain (AD) of the GAL gene activator, Gal4, preventing GAL gene expression. Galactose triggers an association between Gal3 and Gal80, relieving Gal80 inhibition of Gal4. We selected for GAL80 mutants with impaired capacity of Gal80 to bind to...

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Identifiers

PMID: 15695361
DOI: 10.1534/genetics.104.036723
PMCID: PMC1449595

Genes

GAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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