Article
Presence of the functional CASPASE-12 allele in Indian subpopulations.
International journal of immunogenetics - 1 Oct 2012
Yavari M, Brinkley G, Klapstein K D, Hartwig W C, Rao R, Hermel E
Abstract excerpt
Most humans lack a functional CASP12 gene, with the nonfunctional variant (CASP12p1), found in 100% of the Caucasian and east Asian population, and in approximately 80% of people of African descent. However, 20% of Africans carry an intact allele of CASP12, which produces a full-length pro-enzyme and increases the risk of sepsis. We examined CASP12 allele distribution in persons from central and southern Asia and...
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