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Article

Caspase-12 and the inflammatory response to Yersinia pestis.

PloS one - 1 Sept 2009

Ferwerda Bart, McCall Matthew B B, de Vries Maaike C, Hopman Joost, Maiga Boubacar, Dolo Amagana, Doumbo Ogobara, Daou Modibo, de Jong Dirk, Joosten Leo A B, Tissingh Rudi A, Reubsaet Frans A G, Sauerwein Robert, van der Meer Jos W M, van der Ven André J A M, Netea Mihai G

Abstract excerpt

BACKGROUND: Caspase-12 functions as an antiinflammatory enzyme inhibiting caspase-1 and the NOD2/RIP2 pathways. Due to increased susceptibility to sepsis in individuals with functional caspase-12, an early-stop mutation leading to the loss of caspase-12 has replaced the ancient genotype in Eurasia and a significant proportion of individuals from African populations. In African-Americans, it has been shown that...

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Source

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Identifiers

PMID: 19721713
DOI: 10.1371/journal.pone.0006870
PMCID: PMC2730527

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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