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Article

Maturation stage–specific regulation of megakaryopoiesis by pointed-domain Ets proteins

7 Jun 2006

Abstract excerpt

Numerous megakaryocyte-specific genes contain signature Ets-binding sites in their regulatory regions. Fli-1 (friend leukemia integration 1), an Ets transcription factor, is required for the normal maturation of megakaryocytes and controls the expression of multiple megakaryocyte-specific genes. However, in Fli-1-/- mice, early megakaryopoiesis persists, and the expression of the early megakaryocyte-specific...

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Identifiers

PMID: 16757682
DOI: 10.1182/blood-2006-04-019760

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