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Article

GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia.

Stem cell research - 1 May 2016

Manukjan Georgi, Ripperger Tim, Venturini Letizia, Stadler Michael, Göhring Gudrun, Schambach Axel, Schlegelberger Brigitte, Steinemann Doris

Abstract excerpt

Maintenance of hematopoietic stem cells and their potential to give rise to progenitors of differentiated lymphoid and myeloid cells are accomplished by a network of regulatory processes. As a part of this network, the heteromeric transcription factor GA-binding protein (GABP) plays a crucial role in self-renewal of murine hematopoietic and leukemic stem cells. Here, we report the consequences of functional...

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Identifiers

PMID: 27100840
DOI: 10.1016/j.scr.2016.04.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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