Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent.

Molecular and cellular biology - 1 Apr 2003

Seiffert Martina, Custodio Joseph M, Wolf Ingrid, Harkey Michael, Liu Yan, Blattman Joseph N, Greenberg Philip D, Rohrschneider Larry R

Abstract excerpt

Gab proteins are intracellular scaffolding and docking molecules involved in signaling pathways mediated by various growth factor, cytokine, or antigen receptors. Gab3 has been shown to act downstream of the macrophage colony-stimulating factor receptor, c-Fms, and to be important for macrophage differentiation. To analyze the physiological role of Gab3, we used homologous recombination to generate mice deficient...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Specificity
Share to Bone Marrow Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Immunoblotting

Share to Immunocompetence

Share to Macrophage Colony-Stimulating Factor

Share to Organ Specificity

Share to Phosphoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12640125
DOI: 10.1128/MCB.23.7.2415-2424.2003
PMCID: PMC150735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent.PMID 12640125Read ↗

Defective lymphoid development in mice lacking Jak3.Semantic proximity Read ↗

Essential role of Gab1 for signaling by the c-Met receptor in vivo.Semantic proximity Read ↗

Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells.Semantic proximity Read ↗

Distinct requirements for Gab1 in Met and EGF receptor signaling <i>in vivo</i>Semantic proximity Read ↗

GABP transcription factor is required for myeloid differentiation, in part, through its control of Gfi-1 expression.Semantic proximity Read ↗

G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation.Semantic proximity Read ↗

Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells.Semantic proximity Read ↗

The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation.Semantic proximity Read ↗

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.Semantic proximity Read ↗

The absence of the transcription activator TFE3 impairs activation of B cells in vivo.Semantic proximity Read ↗

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.Semantic proximity Read ↗

Peripheral expression of Jak3 is required to maintain T lymphocyte function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.