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Article

Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors.

BMC evolutionary biology - 16 Feb 2007

Baker Michael E, Chandsawangbhuwana Charlie, Ollikainen Noah

Abstract excerpt

BACKGROUND: The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) evolved from a common ancestor. Still not completely understood is how specificity for glucocorticoids (e.g. cortisol) and mineralocorticoids (e.g. aldosterone) evolved in these receptors. RESULTS: Our analysis of several vertebrate GRs and MRs in the context of 3D structures of human GR and MR indicates that with the exception of...

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Identifiers

PMID: 17306029
DOI: 10.1186/1471-2148-7-24
PMCID: PMC1805736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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