Article
A Natural Mutation in Helix 5 of the Ligand Binding Domain of Glucocorticoid Receptor Enhances Receptor-Ligand Interaction.
PloS one - 1 Jan 2016
Reyer Henry, Ponsuksili Siriluck, Kanitz Ellen, Pöhland Ralf, Wimmers Klaus, Murani Eduard
Abstract excerpt
The glucocorticoid receptor (GR) is a central player in the neuroendocrine stress response; it mediates feedback regulation of the hypothalamus-pituitary-adrenal (HPA) axis and physiological actions of glucocorticoids in the periphery. Despite intensive investigations of GR in the context of receptor-ligand interaction, only recently the first naturally occurring gain-of-function substitution, Ala610Val, of the...
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