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Evolutionary history of calcium-sensing receptors unveils hyper/hypocalcemia-causing mutations.

PLoS computational biology - 1 Nov 2024

Bircan Aylin, Kuru Nurdan, Dereli Onur, Selçuk Berkay, Adebali Ogün

Abstract excerpt

Despite advancements in understanding the structure and functions of the Calcium Sensing Receptor (CaSR), gaps persist in our knowledge of the specific functions of its residues. In this study, we used phylogeny-based techniques to identify functionally equivalent orthologs of CaSR, predict residue significance, and compute specificity-determining position (SDP) scores to understand its evolutionary basis. The...

Topics

Receptors, Calcium-Sensing
Phylogeny
Humans
Evolution, Molecular
Mutation
Hypocalcemia
Calcium
Hypercalcemia
Computational Biology
Animals

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PMID: 39531485
DOI: 10.1371/journal.pcbi.1012591
PMCID: PMC11584096

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