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Article

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment.

Clinical pharmacology and therapeutics - 1 Dec 2005

Crettol Séverine, Déglon Jean-Jacques, Besson Jacques, Croquette-Krokkar Marina, Gothuey Isabelle, Hämmig Robert, Monnat Martine, Hüttemann Hardy, Baumann Pierre, Eap Chin B

Abstract excerpt

BACKGROUND AND OBJECTIVE: Recent in vitro studies have suggested an important role of cytochrome P450 (CYP) 2B6 and CYP2C19 in methadone metabolism. We aimed to determine the influence of CYP2B6, CYP2C9, and CYP2C19 genetic polymorphism on methadone pharmacokinetics and on the response to treatment. METHODS: We included 209 patients in methadone maintenance treatment on the basis of their response to treatment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16338275
DOI: 10.1016/j.clpt.2005.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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