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Article

Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study.

Pharmacogenetics and genomics - 1 Feb 2013

Dobrinas Maria, Crettol Séverine, Oneda Beatrice, Lahyani Rachel, Rotger Margalida, Choong Eva, Lubomirov Rubin, Csajka Chantal, Eap Chin B

Abstract excerpt

BACKGROUND: (S)-Methadone, metabolized mainly by CYP2B6, shows a wide interindividual variability in its pharmacokinetics and pharmacodynamics. METHODS: Resequencing of the CYP2B6 gene was performed in 12 and 35 selected individuals with high (S)-methadone plasma exposure and low (S)-methadone plasma exposure, respectively, from a previously described cohort of 276 patients undergoing methadone maintenance...

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Share to Analgesics, Opioid
Share to Chromatography, Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2B6

Share to Metabolic Clearance Rate

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Share to Opioid-Related Disorders

Share to Oxidoreductases, N-Demethylating

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Identifiers

PMID: 23249875
DOI: 10.1097/FPC.0b013e32835cb2e2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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