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Article

Divergent effect of mammalian PLCζ in generating Ca2+ oscillations in somatic cells compared with eggs

4 Jul 2011

Abstract excerpt

Sperm PLCζ (phospholipase Cζ) is a distinct phosphoinositide-specific PLC isoform that is proposed to be the physiological trigger of egg activation and embryo development at mammalian fertilization. Recombinant PLCζ has the ability to trigger Ca²⁺ oscillations when expressed in eggs, but it is not known how PLCζ activity is regulated in sperm or eggs. In the present study, we have transfected CHO...

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PMID: 21692749
DOI: 10.1042/bj20101581

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