Article
Chimeras of sperm PLC reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization
23 Oct 2013
Abstract excerpt
Phospholipase C-zeta (PLCζ) is a sperm-specific protein believed to cause Ca(2+) oscillations and egg activation during mammalian fertilization. PLCζ is very similar to the somatic PLCδ1 isoform but is far more potent in mobilizing Ca(2+) in eggs. To investigate how discrete protein domains contribute to Ca(2+) release, we assessed the function of a series of PLCζ/PLCδ1 chimeras. We examined their ability to...
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