Article
Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes.
Human reproduction (Oxford, England) - 1 Dec 2011
Kashir Junaid, Jones Celine, Lee Hoi Chang, Rietdorf Katja, Nikiforaki Dimitra, Durrans Claire, Ruas Margarida, Tee Sze Tian, Heindryckx Bjorn, Galione Antony, De Sutter Petra, Fissore Rafael A, Parrington John, Coward Kevin
Abstract excerpt
BACKGROUND: Mammalian oocyte activation occurs via a series of intracellular calcium (Ca(2+)) oscillations thought to be induced by a sperm-specific phospholipase C zeta (PLCζ). There is now strong evidence to indicate that certain types of human male infertility are caused by failure of the sperm to activate the oocyte in an appropriate manner. Molecular analysis of the PLCζ gene of a male patient with oocyte...
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