Article
A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990
Roussel M F, Shurtleff S A, Downing J R, Sherr C J
Abstract excerpt
Substitution of phenylalanine for tyrosine-809 in the human colony-stimulating factor 1 receptor (CSF-1R) inhibited its ability to transduce ligand-dependent mitogenic signals in mouse NIH 3T3 cells. When combined with an "activating" mutation at codon 301 that induces constitutive CSF-1R tyrosin...
Topics
- Animals
- Base Sequence
- Cell Division
- Cell Line
- Codon
- DNA-Binding Proteins
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Peptide Mapping
- Phosphatidylinositol 3-Kinases
- Phosphopeptides