Article
Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase.
Molecular and cellular biology - 1 Dec 1997
Davis J N, Rock C O, Cheng M, Watson J B, Ashmun R A, Kirk H, Kay R J, Roussel M F
Abstract excerpt
Substitution of phenylalanine for tyrosine at codon 809 (Y809F) of the human colony-stimulating factor 1 (CSF-1) receptor (CSF-1R) impairs ligand-stimulated tyrosine kinase activity, prevents induction of c-MYC and cyclin D1 genes, and blocks CSF-1-dependent progression through the G1 phase of th...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Division
- Cell Line
- Colony-Stimulating Factors
- Cyclin D1
- DNA Primers
- DNA, Complementary
- Endocytosis
- Genes, myc
- Genetic Complementation Test
- Humans
- Mice
- Molecular Sequence Data