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Article

Cell specific transformation by c-fms activating loop mutations is attributable to constitutive receptor degradation.

Oncogene - 20 May 1999

Morley G M, Uden M, Gullick W J, Dibb N J

Abstract excerpt

Expression of a receptor for human macrophage-colony stimulating factor (M-CSF or CSF-1), containing a point mutation which changes an aspartate to a valine at position 802 of the activating loop of the kinase domain, potently transforms the haemopoietic cell line FDC-P1 yet prevents Rat-2 fibroblast transformation. In order to understand this apparent paradox, aspartate 802 was changed by cassette mutagenesis to...

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Identifiers

PMID: 10340379
DOI: 10.1038/sj.onc.1202646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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