Article
Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807.
The Journal of biological chemistry - 20 Apr 2012
Yu Wenfeng, Chen Jian, Xiong Ying, Pixley Fiona J, Yeung Yee-Guide, Stanley E Richard
Abstract excerpt
Colony-stimulating factor-1 (CSF-1)-stimulated CSF-1 receptor (CSF-1R) tyrosine phosphorylation initiates survival, proliferation, and differentiation signaling pathways in macrophages. Either activation loop Y807F or juxtamembrane domain (JMD) Y559F mutations severely compromise CSF-1-regulated proliferation and differentiation. YEF, a CSF-1R in which all eight tyrosines phosphorylated in the activated receptor...
Topics
- Animals
- Cell Proliferation
- Cell Survival
- Cross-Linking Reagents
- Gene Expression Regulation
- Humans
- Macrophages
- Mice
- Mutagenesis, Site-Directed
- Mutation
- Protein Structure, Tertiary
- Receptor, Macrophage Colony-Stimulating Factor
- Signal Transduction
- Structure-Activity Relationship