Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807.

The Journal of biological chemistry - 20 Apr 2012

Yu Wenfeng, Chen Jian, Xiong Ying, Pixley Fiona J, Yeung Yee-Guide, Stanley E Richard

Abstract excerpt

Colony-stimulating factor-1 (CSF-1)-stimulated CSF-1 receptor (CSF-1R) tyrosine phosphorylation initiates survival, proliferation, and differentiation signaling pathways in macrophages. Either activation loop Y807F or juxtamembrane domain (JMD) Y559F mutations severely compromise CSF-1-regulated proliferation and differentiation. YEF, a CSF-1R in which all eight tyrosines phosphorylated in the activated receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Cell Survival

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cross-Linking Reagents

Share to Macrophages

Share to Mutagenesis, Site-Directed

Share to Receptor, Macrophage Colony-Stimulating Factor

Share to Structure-Activity Relationship

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 22375015
DOI: 10.1074/jbc.M112.355610
PMCID: PMC3340183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807.PMID 22375015Read ↗

CSF-1 receptor structure/function in MacCsf1r-/- macrophages: regulation of proliferation, differentiation, and morphology.Semantic proximity Read ↗

A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.Semantic proximity Read ↗

Colony-stimulating factor-1 (CSF-1) receptor-mediated macrophage differentiation in myeloid cells: a role for tyrosine 559-dependent protein phosphatase 2A (PP2A) activity.Semantic proximity Read ↗

Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line.Semantic proximity Read ↗

Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells.Semantic proximity Read ↗

The colony-stimulating factor 1 receptor: pleiotropy of signal-response coupling.Semantic proximity Read ↗

Expression of a Y559F mutant CSF-1 receptor in M1 myeloid cells: a role for Src kinases in CSF-1 receptor-mediated differentiation.Semantic proximity Read ↗

Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression.Semantic proximity Read ↗

Total, not isoform-specific, Lyn expression by macrophages promotes TLR activation and restricts proliferationSemantic proximity Read ↗

Alterations in CSF-1 receptor expression and protein tyrosine phosphorylation in autonomous mutants of a CSF-1 dependent macrophage cell line.Semantic proximity Read ↗

Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1.Semantic proximity Read ↗

Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.